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ACE Inhibitors (ACEIs) are medications that end in -pril, including lisinopril, captopril, ramipril, and enalapril. ACE inhibitors work by blocking angiotensin converting enzyme or ACE, which blocks the conversion of angiotensin I to its active counterpart, angiotensin II. Reduced angiotensin II levels cause vasodilation, and reduced downstream signaling of aldosterone further reduces blood volume. The overall effect of treatment with an ACE inhibitor is lowering of blood pressure. Clinically, ACE inhibitors are used to treat hypertension and heart failure. Side effects include a dry cough, angioedema, and hyperkalemia. Notably, ACE inhibitors are teratogenic and should not be used during pregnancy.
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00:00 Introduction
00:19 ACE Inhibitors
03:03 -pril Ending
03:52 Lowers Blood Pressure
05:07 Treats Heart Failure
08:01 Dry Cough
08:48 Causes Angioedema
09:30 Teratogenic
10:06 Increases Potassium
11:11 Causes Dizziness
11:54 Summary
