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Title:The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast
Duration:02:17:35
Viewed:327,412
Published:12-06-2023
Source:Youtube

In this episode, I discuss methylenedioxymethamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the extremely dangerous additives (e.g., fentanyl) now commonly found in black market MDMA. This should be of interest to those curious about MDMA, neuropharmacology, the origins of emotional processing in the brain, empathy, PTDS, neuroplasticity, mental health and psychiatry. #HubermanLab #Science Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix Sleep: https://helixsleep.com/huberman ROKA: https://roka.com/huberman HVMN: https://hvmn.com/huberman LMNT: https://drinklmnt.com/huberman Momentous: https://livemomentous.com/huberman Social & Website Instagram - https://www.instagram.com/hubermanlab Twitter - https://twitter.com/hubermanlab Facebook - https://www.facebook.com/hubermanlab TikTok - https://www.tiktok.com/@hubermanlab Website - https://hubermanlab.com Newsletter - https://hubermanlab.com/neural-network Articles A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus: https://bit.ly/3oV8zSl Effects of MDMA on sociability and neural response to social threat and social reward: https://bit.ly/3NlOYUC The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity: https://bit.ly/42yMEhl Distinct neural mechanisms for the prosocial and rewarding properties of MDMA: https://bit.ly/3NlNERM Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans: https://bit.ly/42AF6e0 RETRACTED: Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ("Ecstasy"): https://bit.ly/3J9PTVU Science forced to retract article on “ecstasy”: https://bit.ly/3oRRpVM Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs: https://bit.ly/3P93gcM MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study: https://go.nature.com/3WqI2Zd The effects of MDMA-assisted therapy on alcohol and substance use in a phase 3 trial for treatment of severe PTSD: https://bit.ly/42wqeNP Books PIHKAL: A Chemical Love Story: https://amzn.to/45ZY80w Trauma: The Invisible Epidemic: https://amzn.to/45VdgfA The Body Keeps the Score: https://amzn.to/3XgH5Dz Other Resources Multidisciplinary Association for Psychedelic Studies (MAPS): https://maps.org Participate in a MAPS trial: https://maps.org/take-action/participate-in-trial Huberman Lab episode on psilocybin: https://bit.ly/43yP80G Huberman Lab episode on psychedelics for mental health: https://bit.ly/3NqC3Rz Huberman Lab episode on dopamine, mindset & drive: https://bit.ly/3IqQzVb Huberman Lab episode on leveraging dopamine: https://bit.ly/3P3dCuD Timestamps 00:00:00 MDMA “Ecstasy” 00:04:37 Sponsors: Helix Sleep, ROKA, HVMN 00:08:18 MDMA History & Synthesis; Legality 00:14:45 MDMA, Methamphetamine (Meth), Dopamine & Serotonin 00:23:30 MDMA vs Psychedelics vs Ketamine 00:26:54 MDMA & Serotonin 1B Receptor, Subjective Feelings, Trauma 00:33:36 Sponsor: AG1 00:34:51 Amygdala & Threat Detection, Pro-Social Behavior, MDMA Dosages 00:45:48 Interoception, MDMA & Post-Traumatic Stress Disorder (PTSD) 00:52:36 Long-Term Effects, Threat Detection & PTSD 00:56:14 MDMA, Social Connection & Empathy; Meth, SSRIs 01:06:10 Sponsor: LMNT 01:07:22 Oxytocin & MDMA 01:16:10 Safety & Neurotoxicity; Recreational Use, Caffeine & Fentanyl 01:26:36 Is MDMA Neurotoxic?; Poly-Pharmacology, Body Temperature 01:37:07 Post-MDMA “Crash”, Prolactin & P 5 P 01:43:07 PTSD & Trauma; Talk Therapy, SSRIs 01:54:09 PTSD Treatment: Talk Therapy + MDMA 02:02:46 MDMA & Addiction; Dissociative PTSD & Empathy 02:09:47 Side-Effects?, MDMA Efficacy & Legality 02:15:22 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Disclaimer: https://hubermanlab.com/disclaimer



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