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Antiepileptic drugs, also referred to as anticonvulsants, are a diverse group of medications used in the treatment of epileptic seizures. Antiepileptics work in a number of different ways to inhibit or slow down neuronal firing to prevent seizures from occurring. This pharmacology lecture covers topics such as pathophysiology and classification of seizures, action potential, excitatory and inhibitory neurotransmission (role of glutamate and GABA), voltage-gated sodium and calcium channels, AMPA and NMDA receptors, mechanism of action and side effects of antiepileptic drugs. Drugs mentioned include; Carbamazepine, Oxcarbazepine, Lamotrigine, Phenytoin, Topiramate, Valproic acid, Zonisamide, Gabapentin, Pregabalin, Levetiracetam, Felbamate, Tiagabine, and Vigabatrin.
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0:00 Seizure classification
1:07 Excitatory synapse
2:44 Inhibitory neuron
3:51 Antiepileptics - mechanism of action
7:26 Side effects
